Bidirectional relationship between olfaction and Parkinson's disease.

ABSTRACT:

Background

Hyposmia (loss of smell) is a common early symptom of Parkinson's disease (PD). The shared genetic architecture between hyposmia and PD is unknown.

Methods

We leveraged genome-wide association study (GWAS) results for self-assessment of 'ability to smell' and PD diagnosis. Linkage disequilibrium score regression (LDSC) and Local Analysis of [co]Variant Association (LAVA) were used to identify genome-wide and local genetic correlations. Mendelian randomization was used to identify potential causal relationships.

Results

LDSC found that sense of smell negatively correlated at a genome-wide level with PD. LAVA found negative correlations in four genetic loci near GBA1, ANAPC4, SNCA, and MAPT. Using Mendelian randomization we found e

SUBMITTER: Kim JJ 

PROVIDER: S-EPMC10615003 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature