Regional quantification of cardiac metabolism with hyperpolarized [1-¹³C]-pyruvate MRI evaluated in an oral glucose challenge.

ABSTRACT:

Background

The heart has metabolic flexibility, which is influenced by fed/fasting states, and pathologies such as myocardial ischemia and hypertrophic cardiomyopathy (HCM). Hyperpolarized (HP) ¹³C-pyruvate MRI is a promising new tool for non-invasive quantification of myocardial glycolytic and Krebs cycle flux. However, human studies of HP ¹³C-MRI have yet to demonstrate regional quantification of metabolism, which is important in regional ischemia and HCM patients with asymmetric septal/apical hypertrophy.

Methods

We developed and applied methods for whole-heart imaging of ¹³C-pyruvate, ¹³C-lactate and ¹³C-bicarbonate, following intravenous administration of [1-¹³C]-pyruvate. The image acquisition used an au

SUBMITTER: Larson PEZ 

PROVIDER: S-EPMC10615005 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature