Regulation of the somatotropic axis by MYC-mediated miRNA repression.

ABSTRACT: The transcription factor MYC is overexpressed in many human cancers and has a significant causal role in tumor incidence and progression. In contrast, Myc ^+/- heterozygous mice, which have decreased MYC expression, exhibit a 10-20% increase in lifespan and a decreased incidence or progression of several age-related diseases. Myc heterozygous mice were also reported to have decreased mTOR and IGF1 signaling, two pathways whose reduced activity is associated with longevity in diverse species. Given MYC's downstream role in these pathways, the downregulation of mTOR and IGF1 signaling in Myc heterozygotes suggests the presence of feedback loops within this regulatory network. In this communication we provide further evidence that the reduction of Myc exp

SUBMITTER: Petrashen AP 

PROVIDER: S-EPMC10615138 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature