CCR1 mediates Muller cell activation and photoreceptor cell death in macular and retinal degeneration.

ABSTRACT: Mononuclear cells are involved in the pathogenesis of retinal diseases, including age-related macular degeneration (AMD). Here, we examined the mechanisms that underlie macrophage-driven retinal cell death. Monocytes were extracted from patients with AMD and differentiated into macrophages (hMdɸs), which were characterized based on proteomics, gene expression, and ex vivo and in vivo properties. Using bioinformatics, we identified the signaling pathway involved in macrophage-driven retinal cell death, and we assessed the therapeutic potential of targeting this pathway. We found that M2a hMdɸs were associated with retinal cell death in retinal explants and following adoptive transfer in a photic injury model. Moreover, M2a hMdɸs express several CCRI (C-C chemokine receptor type 1) ligands.

SUBMITTER: Elbaz-Hayoun S 

PROVIDER: S-EPMC10615370 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature