Effect of combined tobacco use and type 2 diabetes mellitus on prevalent fibrosis in patients with MASLD.

ABSTRACT:

Background

Several studies have investigated the independent effect of cigarette smoking or type 2 diabetes mellitus (T2DM) on MASLD. However, the interaction effect between tobacco consumption and T2DM on MASLD severity remains underexplored. In this study, we assessed the combined effect of tobacco use and T2DM on hepatic fibrosis in MASLD.

Methods

We conducted a single-center retrospective cross-sectional analysis of eligible participants from the Mass General Brigham Fibroscan© database. The participants were divided into 3 groups: those with T2DM and a history of tobacco use (primary exposure group), those with T2DM but no history of tobacco use (secondary exposure group), and those without T2DM and no history of tobacco use (reference group). An additional model was de

SUBMITTER: Balogun O 

PROVIDER: S-EPMC10615418 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature