Mineral and bone metabolism markers and mortality in diabetic patients on haemodialysis.

ABSTRACT:

Background

Diabetic patients on haemodialysis have a higher risk of mortality than non-diabetic patients. The aim of this COSMOS (Current management of secondary hyperparathyroidism: a multicentre observational study) analysis was to assess whether bone and mineral laboratory values [calcium, phosphorus and parathyroid hormone (PTH)] contribute to this risk.

Methods

COSMOS is a multicentre, open-cohort, 3-year prospective study, which includes 6797 patients from 227 randomly selected dialysis centres in 20 European countries. The association between mortality and calcium, phosphate or PTH was assessed using Cox proportional hazard regression models using both penalized splines smoothing and categorization according to KDIGO guidelines. The effect modification of the associat

SUBMITTER: Martin-Carro B 

PROVIDER: S-EPMC10615625 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature