Association of Rare Variants in ARSA with Parkinson's Disease.

ABSTRACT:

Background

Several lysosomal genes are associated with Parkinson's disease (PD), yet the association between PD and ARSA remains unclear.

Objectives

To study rare ARSA variants in PD.

Methods

To study rare ARSA variants (minor allele frequency < 0.01) in PD, we performed burden analyses in six independent cohorts with 5801 PD patients and 20,475 controls, followed by a meta-analysis.

Results

We found evidence for associations between functional ARSA variants and PD in four cohorts (P ≤ 0.05 in each) and in the meta-analysis (P = 0.042). We also found an association between loss-of-function variants and PD in the United Kingdom Biobank cohort (P = 0.005) and in the meta-analysis (P = 0.049). These results should be interpreted with caution as no association surv

SUBMITTER: Senkevich K 

PROVIDER: S-EPMC10615669 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature