Acan downregulation in parvalbumin GABAergic cells reduces spontaneous recovery of fear memories.

ABSTRACT: While persistence of fear memories is essential for survival, a failure to inhibit fear in response to harmless stimuli is a feature of anxiety disorders. Extinction training only temporarily suppresses fear memory recovery in adults, but it is highly effective in juvenile rodents. Maturation of GABAergic circuits, in particular of parvalbumin-positive (PV⁺) cells, restricts plasticity in the adult brain, thus reducing PV⁺ cell maturation could promote the suppression of fear memories following extinction training in adults. Epigenetic modifications such as histone acetylation control gene accessibility for transcription and help couple synaptic activity to changes in gene expression. Histone deacetylase 2 (Hdac2), in particular, restrains both structural and function

SUBMITTER: Lavertu-Jolin M 

PROVIDER: S-EPMC10615765 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature