Scorpion venom heat-resistant peptide alleviates mitochondrial dynamics imbalance induced by PM_2.5 exposure by downregulating the PGC-1α/SIRT3 signaling pathway.

ABSTRACT:

Background

Epidemiological inquiry reveals that neuroinflammation and mitochondrial dysfunction caused by PM_2.5 exposure are associated with Alzheimer's disease. Nevertheless, the molecular mechanisms of mitochondrial dynamics and neuroinflammation induced by PM_2.5 exposure remain elusive. In this study, our objective was to explore the impact of PM_2.5 on mitochondrial dynamics and neuroinflammation, while also examining the reparative potential of scorpion venom heat-resistant synthetic peptide (SVHRSP).

Methods

Western blot and quantitative reverse transcription polymerase chain reaction (RT-qPCR) were employed to ascertain the protein and gene levels of IL-1β, IL-6, and TNF-α in BV2 cells. The concentration of IL-6 in the supernatant of th

SUBMITTER: Huang L 

PROVIDER: S-EPMC10615811 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature