Metabolic disturbance and transcriptomic changes induced by methyl triclosan in human hepatocyte L02 cells.

ABSTRACT:

Purpose

Methyl triclosan (MTCS) is one of the biomethylated by-products of triclosan (TCS). With the increasing use of TCS, the adverse effects of MTCS have attracted extensive attention in recent years. The purpose of this study was to investigate the cytotoxicity of MTCS and to explore the underlining mechanism using human hepatocyte L02 cells as in vitro model.

Results

The cytotoxicity results revealed that MTCS could inhibit cell viability, disturb the ratio of reduced glutathione (GSH) and oxidized glutathione (GSSG), and reduce the mitochondrial membrane potential (MMP) in a dose-dependent manner. In addition, MTCS exposure significantly promoted the cellular metabolic process, including enhanced conversion of glucose to lactic acid, and elevated content of intracellul

SUBMITTER: An J 

PROVIDER: S-EPMC10615820 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature