DNA methylome profiling in occupational radon exposure miners using an Illumina Infinium Methylation EPIC BeadChip.

ABSTRACT:

Background

A causal relationship between occupational radon exposure in underground miners and lung cancer risk has been demonstrated through large cohort epidemiological studies. However, the mechanisms by which radon exposure causes adverse effects on lung tissue remain unclear. Epigenetic alterations such as DNA methylation may provide new insights into interactions at molecular levels induced by prolonged radon exposure.

Methods

We used the Illumina Infinium Human Methylation 850 K BeadChip to detect and compare genome-wide DNA methylation profiles in peripheral blood samples from underground miners (n = 14) and aboveground workers (n = 9).

Results

The average concentration of radon in underground workplaces was significantly higher than that of aboveground places

SUBMITTER: Zhang P 

PROVIDER: S-EPMC10615836 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature