Sensory deprivation arrests cellular and synaptic development of the night-vision circuitry in the retina.

ABSTRACT: Experience regulates synapse formation and function across sensory circuits. How inhibitory synapses in the mammalian retina are sculpted by visual cues remains unclear. By use of a sensory deprivation paradigm, we find that visual cues regulate maturation of two GABA synapse types (GABA_A and GABA_C receptor synapses), localized across the axon terminals of rod bipolar cells (RBCs)-second-order retinal neurons integral to the night-vision circuit. Lack of visual cues causes GABA_A synapses at RBC terminals to retain an immature receptor configuration with slower response profiles and prevents receptor recruitment at GABA_C synapses. Additionally, the organizing protein for both these GABA synapses, LRRTM4, is not clustered at dark-reared RBC synapse

SUBMITTER: Wisner SR 

PROVIDER: S-EPMC10615854 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature