Signaling protein abundance modulates the strength of the spindle assembly checkpoint.

ABSTRACT: During mitosis, unattached kinetochores in a dividing cell signal to the spindle assembly checkpoint (SAC) to delay anaphase onset and prevent chromosome missegregation.^1,2,3,4 The signaling activity of these kinetochores and the likelihood of chromosome missegregation depend on the amount of SAC signaling proteins each kinetochore recruits.^5,6,7,8 Therefore, factors that control SAC protein recruitment must be thoroughly understood. Phosphoregulation of kinetochore and SAC signaling proteins due to the concerted action of many kinases and phosphatases is a significant determinant of the SAC protein recruitment to signaling kinetochores.<

SUBMITTER: Jema S 

PROVIDER: S-EPMC10615864 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature