Platinum(IV)-Gold(I) Agents with Promising Anticancer Activity: Selected Studies in 2D and 3D Triple-Negative Breast Cancer Models.

ABSTRACT: New heterometallic binuclear and trinuclear platinum(IV)-gold(I) compounds of the type [Pt(L)_n Cl₂ (OH){(OOC-4-C₆ H₄ -PPh₂ )AuCl}_x ] (L=NH₃ , n=2; x=1, 2; L=diaminocyclohexane, DACH, n=1; x=2) are described. These compounds are cytotoxic and selective against a small panel of renal, bladder, ovarian, and breast cancer cell lines. We selected a trinuclear PtAu₂ compound containing the Pt^IV core based on oxaliplatin, to further investigate its cell-death pathway, cell and organelle uptake and anticancer effects against the triple-negative breast cancer (TNBC) MDA-MB-231 cell line. This compound induces apoptosis and accumulates mainly in the nucleus and mitochondria. It also exerts remarkable a

SUBMITTER: Lopez-Hernandez JE 

PROVIDER: S-EPMC10615877 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature