Adhesion-based capture stabilizes nascent microvilli at epithelial cell junctions.

ABSTRACT: To maximize solute transport, epithelial cells build an apical "brush border," where thousands of microvilli are linked to their neighbors by protocadherin-containing intermicrovillar adhesion complexes (IMACs). Previous studies established that the IMAC is needed to build a mature brush border, but how this complex contributes to the accumulation of new microvilli during differentiation remains unclear. We found that early in differentiation, mouse, human, and porcine epithelial cells exhibit a marginal accumulation of microvilli, which span junctions and interact with protrusions on neighboring cells using IMAC protocadherins. These transjunctional IMACs are highly stable and reinforced by tension across junctions. Finally, long-term live imaging showed that the accumulation of microvill

SUBMITTER: Cencer CS 

PROVIDER: S-EPMC10615885 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature