ROS-producing nanomaterial engineered from Cu(I) complexes with P₂N₂-ligands for cancer cells treating.

ABSTRACT: The work presents core-shell nanoparticles (NPs) built from the novel Cu(I) complexes with cyclic P₂N₂-ligands (1,5-diaza-3,7-diphosphacyclooctanes) that can visualize their entry into cancer and normal cells using a luminescent signal and treat cells by self-enhancing generation of reactive oxygen species (ROS). Variation of P- and N-substituents in the series of P₂N₂-ligands allows structure optimization of the Cu(I) complexes for the formation of the luminescent NPs with high chemical stability. The non-covalent modification of the NPs with triblock copolymer F-127 provides their high colloidal stability, followed by efficient cell internalization of the NPs visualized by their blue (⁓450 nm) luminescence. The cytotoxic effects of the NPs towa

SUBMITTER: Faizullin BA 

PROVIDER: S-EPMC10616039 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature