PhysiBoSS 2.0: a sustainable integration of stochastic Boolean and agent-based modelling frameworks.

ABSTRACT: In systems biology, mathematical models and simulations play a crucial role in understanding complex biological systems. Different modelling frameworks are employed depending on the nature and scales of the system under study. For instance, signalling and regulatory networks can be simulated using Boolean modelling, whereas multicellular systems can be studied using agent-based modelling. Herein, we present PhysiBoSS 2.0, a hybrid agent-based modelling framework that allows simulating signalling and regulatory networks within individual cell agents. PhysiBoSS 2.0 is a redesign and reimplementation of PhysiBoSS 1.0 and was conceived as an add-on that expands the PhysiCell functionalities by enabling the simulation of intracellular cell signalling using MaBoSS while keeping a decoupled, main

SUBMITTER: Ponce-de-Leon M 

PROVIDER: S-EPMC10616087 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature