Returning incidentally discovered Hepatitis C RNA-seq results to COPDGene study participants.

ABSTRACT: The consequences of returning infectious pathogen test results identified incidentally in research studies have not been well-studied. Concerns include identification of an important health issue for individuals, accuracy of research test results, public health impact, potential emotional distress for participants, and need for IRB permissions. Blood RNA-sequencing analysis for non-human RNA in 3984 participants from the COPDGene study identified 228 participants with evidence suggestive for hepatitis C virus (HCV) infection. We hypothesized that incidentally discovered HCV results could be effectively returned to COPDGene participants with attention to the identified concerns. In conjunction with a COPDGene Participant Advisory Panel, we developed and obtained IRB approval for a process o

SUBMITTER: Silverman EK 

PROVIDER: S-EPMC10616181 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature