Epigenome-wide association study of peripheral immune cell populations in Parkinson's disease.

ABSTRACT: Understanding the contribution of immune mechanisms to Parkinson's disease pathogenesis is an important challenge, potentially of major therapeutic implications. To further elucidate the involvement of peripheral immune cells, we studied epigenome-wide DNA methylation in isolated populations of CD14⁺ monocytes, CD19⁺ B cells, CD4⁺ T cells, and CD8⁺ T cells from Parkinson's disease patients and healthy control participants. We included 25 patients with a maximum five years of disease duration and 25 controls, and isolated four immune cell populations from each fresh blood sample. Epigenome-wide DNA methylation profiles were generated from 186 samples using the Illumina MethylationEpic array and association with disease status was tested using line

SUBMITTER: Andersen MS 

PROVIDER: S-EPMC10616224 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature