Transcriptional signature of early cisplatin drug-tolerant persister cells in lung adenocarcinoma.

ABSTRACT: Resistance to cisplatin is the main cause of treatment failure in lung adenocarcinoma. Drug-tolerant-persister (DTP) cells are responsible for intrinsic resistance, since they survive the initial cycles of treatment, representing a reservoir for the emergence of clones that display acquired resistance. Although the molecular mechanisms of DTP cells have been described, few studies have investigated the earliest molecular alterations of DTP cells in intrinsic resistance to cisplatin. In this work, we report a gene expression signature associated with the emergence of cisplatin-DTP cells in lung adenocarcinoma cell lines. After a single exposure to cisplatin, we sequenced the transcriptome of cisplatin-DTPs to identify differentially expressed genes. Bioinformatic analysis revealed that earl

SUBMITTER: Chavez-Dominguez R 

PROVIDER: S-EPMC10616253 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature