Correlative CD4 and CD8 T-cell immunodominance in humans and mice: Implications for preclinical testing.

ABSTRACT: Antigen-specific T-cell recognition is restricted by Major Histocompatibility Complex (MHC) molecules, and differences between CD4 and CD8 immunogenicity in humans and animal species used in preclinical vaccine testing are yet to be fully understood. In this study, we addressed this matter by analyzing experimentally identified epitopes based on published data curated in the Immune Epitopes DataBase (IEDB) database. We first analyzed SARS-CoV-2 spike (S) and nucleoprotein (N), which are two common targets of the immune response and well studied in both human and mouse systems. We observed a weak but statistically significant correlation between human and H-2^b mouse T-cell responses (CD8 S specific (r = 0.206, p = 1.37 × 10^-13); CD4 S specific (r = 0.118, p = 2.63 × 10

SUBMITTER: Neto TAP 

PROVIDER: S-EPMC10616275 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature