Real-world utilization of guideline-directed genetic testing in inherited cardiovascular diseases.

ABSTRACT:

Background

Cardiovascular disease continues to be the leading cause of death globally. Clinical practice guidelines aimed at improving disease management and positively impacting major cardiac adverse events recommend genetic testing for inherited cardiovascular conditions such as dilated cardiomyopathy (DCM), hypertrophic cardiomyopathy (HCM), long QT syndrome (LQTS), hereditary amyloidosis, and familial hypercholesterolemia (FH); however, little is known about how consistently practitioners order genetic testing for these conditions in routine clinical practice. This study aimed to assess the adoption of guideline-directed genetic testing for patients diagnosed with DCM, HCM, LQTS, hereditary amyloidosis, or FH.

Methods

This retrospective cohort study captured real-world e

SUBMITTER: Longoni M 

PROVIDER: S-EPMC10616303 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature