Association between XRCC1 Arg399Gln polymorphism with prognosis of head and neck squamous cell carcinomas: A meta-analysis.

ABSTRACT:

Objective

The X-ray repair cross complementing group 1 (XRCC1) gene is involved in DNA repair. Defects in DNA repair may lead to head and neck squamous cell carcinomas (HNSCCs). Several researches have focused on relationship between XRCC1 Arg399Gln genetic polymorphism with HNSCC's prognosis with conflicting results. So, the aim of the present meta-analysis was evaluation of relationship between XRCC1 Arg399Gln polymorphism with HNSCC's prognosis.

Methods

Published articles up to July 2022 were systematically searched through international databases like PubMed, Web of Science, Scopus, etc. I² test was applied to assess the heterogeneity. Data were analyzed using random effects model. Funnel plots and Egger test were appl

SUBMITTER: Najafi-Ghobadi K 

PROVIDER: S-EPMC10616328 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature