Plasma exosomal miR-1290 and miR-29c-3p as diagnostic biomarkers for lung cancer.

ABSTRACT:

Background

Enhancing the diagnostic efficacy of early-stage lung cancer is crucial for improving prognosis. The objective of this study was to ascertain dependable exosomal miRNAs as biomarkers for the diagnosis of lung cancer.

Methods

Exosomal miRNA candidates were identified through miRNA sequencing and subsequently validated in various case-control sets using real-time quantitative reverse transcription-polymerase chain reaction (RT-qPCR). The correlation between the expression of exosomal miRNAs and the clinicopathological features of lung cancer was investigated. To assess the diagnostic efficacy of exosomal miRNAs for lung cancer, the receiver operating characteristic (ROC) curve analysis was conducted. The optimal cutoff value of exosomal miRNAs was determined in the

SUBMITTER: Zhang Q 

PROVIDER: S-EPMC10616353 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature