Investigation of the causal relationship between osteocalcin and dementia: A Mendelian randomization study.

ABSTRACT:

Objective

Basic medical studies have reported an improved effect of osteocalcin on cognition. We explored the causal link between osteocalcin and dementia via the implementation of Mendelian randomization methodology.

Methods

Genome-wide association studies were employed to identify single nucleotide polymorphisms (SNPs) showing significant correlations with osteocalcin. Subsequently, A two-sample Mendelian randomization analysis was conducted utilizing the inverse-variance-weighted (IVW) technique to assess the causal relationship between osteocalcin and various types of dementia, including Alzheimer's disease (AD), Parkinson's disease (PD), Lewy body dementia (LBD), and vascular dementia (VD). This approach aimed to minimize potential sources of confounding bias and provid

SUBMITTER: Liu W 

PROVIDER: S-EPMC10616355 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature