Dataset Information

Dual targeting of H₂S synthesizing enzymes; cystathionine β-synthase and cystathionine γ-lyase by miR-939-5p effectively curbs triple negative breast cancer.

ABSTRACT:

Introduction

Hydrogen sulfide (H₂S) has been recently scrutinized for its critical role in aggravating breast cancer (BC) tumorigenicity. Several cancers aberrantly express H₂S synthesizing enzymes; Cystathionine-β-synthase (CBS) and cystathionine-γ-lyase (CSE). However, their levels and interdependence in BC require further studies.

Objectives

Firstly, this study aimed to demonstrate a comparative expression profile of H₂S synthesizing enzymes in BC vs normal tissue. Moreover, to investigate the reciprocal relationship between CBS and CSE and highlight the importance of dual targeting. Finally, to search for a valid dual repressor of the H₂S synthesizing enzymes that could cease H₂S production and reduce TNBC pathogenic

SUBMITTER: Nafea H

PROVIDER: S-EPMC10616356 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature

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Dataset Information

Dual targeting of H₂S synthesizing enzymes; cystathionine β-synthase and cystathionine γ-lyase by miR-939-5p effectively curbs triple negative breast cancer.

Introduction

Objectives

OmicsDI is part of the ELIXIR infrastructure

Tweets

Dataset Information

Dual targeting of H2S synthesizing enzymes; cystathionine β-synthase and cystathionine γ-lyase by miR-939-5p effectively curbs triple negative breast cancer.

Introduction

Objectives

OmicsDI is part of the ELIXIR infrastructure

Tweets

Dual targeting of H₂S synthesizing enzymes; cystathionine β-synthase and cystathionine γ-lyase by miR-939-5p effectively curbs triple negative breast cancer.