Fibroblast Growth Factor 23 and Risk of Heart Failure Subtype: The CRIC (Chronic Renal Insufficiency Cohort) Study.

ABSTRACT:

Rationale & objective

Heart failure (HF) is an important cause of morbidity and mortality among individuals with chronic kidney disease (CKD). A large body of evidence from preclinical and clinical studies implicates excess levels of fibroblast growth factor 23 (FGF23) in HF pathogenesis in CKD. It remains unclear whether the relationship between elevated FGF23 levels and HF risk among individuals with CKD varies by HF subtype.

Study design

Prospective cohort study.

Settings & participants

A total of 3,502 participants were selected in the Chronic Renal Insufficiency Cohort study.

Exposure

Baseline plasma FGF23.

Outcomes

Incident HF by subtype and total rate of HF hospitalization. HF was categorized as HF with preserved ejection fraction (HFpEF, ejection

SUBMITTER: Leidner AS 

PROVIDER: S-EPMC10616385 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature