Structured Moderate Exercise and Biomarkers of Kidney Health in Sedentary Older Adults: The Lifestyle Interventions and Independence for Elders Randomized Clinical Trial.

ABSTRACT:

Rationale & objective

In the Lifestyle Interventions and Independence for Elders (LIFE) trial, a structured exercise intervention slowed kidney function decline in sedentary older adults. Biomarkers of kidney health could distinguish potential mechanisms for this beneficial effect.

Study design

Randomized controlled trial.

Setting & population

A total of 1,381 sedentary adults aged 70-89 years enrolled in the LIFE trial.

Intervention

Structured, 2-year, moderate-intensity exercise intervention versus health education.

Outcomes

Physical activity was measured by step count. Primary outcomes were changes in 14 serum and urine biomarkers of kidney health collected at baseline, year 1, and year 2. We determined the effect of randomization on changes in kidney

SUBMITTER: Sheshadri A 

PROVIDER: S-EPMC10616412 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature