Copeptin, Natriuretic Peptides, and Cardiovascular Outcomes in Patients With CKD: The German Chronic Kidney Disease (GCKD) Study.

ABSTRACT:

Rationale & objective

Copeptin and Midrange pro-atrial natriuretic peptide (MR-pro-ANP) are associated with outcomes independently of N-terminal pro-brain natriuretic peptide (NT-pro-BNP) in patients with heart failure (HF). The value of these markers in patients with chronic kidney disease (CKD) has not been studied.

Study design

Prospective cohort study.

Setting & participants

A total of 4,417 patients enrolled in the German Chronic Kidney Disease (GCKD) study with an estimated glomerular filtration rate of 30-60 mL/min/1.73m² or overt proteinuria (urinary albumin-creatinine ratio >300mg/g or equivalent).

Exposures

Copeptin, MR-pro-ANP, and NT-pro-BNP levels were measured in baseline samples.

Outcomes

Noncardiovascular death, cardiovascular

SUBMITTER: Schneider MP 

PROVIDER: S-EPMC10616426 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature