Venous bicarbonate and CKD progression: a longitudinal analysis by the group-based trajectory model.

ABSTRACT:

Background

Metabolic acidosis accelerates chronic kidney disease (CKD) progression towards kidney failure in animal models. Clinical trials testing the effect of bicarbonate on kidney outcomes are underpowered and/or of suboptimal quality. On the other hand, observational studies testing the same hypothesis are generally based on bicarbonate measured at a single time point.

Methods

We studied the longitudinal relationship between repeated venous bicarbonate levels and a predefined composite renal outcome (a ≥30% estimated glomerular filtration rate reduction, dialysis or transplantation) by using group-based trajectory model (GBTM) analysis. The GBTM analysis was used to classify patients based on individual bicarbonate levels over time. The relationship between trajectory g

SUBMITTER: D'Arrigo G 

PROVIDER: S-EPMC10616435 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature