Association between incident depression and clinical outcomes in patients with chronic kidney disease.

ABSTRACT:

Background

Depression is highly prevalent and related to increased morbidity and mortality in patients on dialysis, but less is known among patients with earlier stages of CKD. This study investigated the associations between depression and clinical outcomes in patients with CKD not receiving dialysis.

Methods

We identified 157 398 adults with CKD stages 3-5 not previously diagnosed with depression from the Stockholm CREAtinine Measurements (SCREAM) project. The primary outcomes included hospitalization, CKD progression (>40% decline in eGFR, initiation of kidney replacement therapy, or death due to CKD), major adverse cardiovascular events (MACE; myocardial infarction, stroke, or cardiovascular death), and all-cause mortality. Survival analyses were used to estimate the ass

SUBMITTER: Zhu N 

PROVIDER: S-EPMC10616442 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature