Cystatin C-based estimated glomerular filtration rate and risk of stroke in the general population: a prospective cohort study.

ABSTRACT:

Background

Previous results on the association between the estimated glomerular filtration rate (eGFR) and stroke are mixed. Most studies derived the eGFR from serum creatinine, which is affected by non-kidney determinants and thus has possibly biased the association with stroke risk.

Methods

In this cohort study, we included 429 566 UK Biobank participants (94.5% white, 54% women, age 56 ± 8 years) free of stroke at enrollment. The eGFR_cys and eGFR_cr were calculated with serum cystatin C and creatinine, respectively. Outcomes of interest were risk of total stroke and subtypes. We investigated the linear and nonlinear associations using Cox proportional hazards models and restricted cubic splines, corrected for regression dilution bias.

Results

D

SUBMITTER: Liao J 

PROVIDER: S-EPMC10616444 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature