Copeptin in autosomal dominant polycystic kidney disease: real-world experiences from a large prospective cohort study.

ABSTRACT:

Background

The identification of new biomarkers in autosomal-dominant polycystic kidney disease (ADPKD) is crucial to improve and simplify prognostic assessment as a basis for patient selection for targeted therapies. Post hoc analyses of the TEMPO 3:4 study indicated that copeptin could be one of those biomarkers.

Methods

Copeptin was tested in serum samples from patients of the AD(H)PKD study. Serum copeptin levels were measured using a time-resolved amplified cryptate emission (TRACE)-based assay. In total, we collected 711 values from 389 patients without tolvaptan treatment and a total of 243 values (of which 64 were pre-tolvaptan) from 94 patients on tolvaptan. These were associated with rapid progression and disease-causing gene variants and their predictive ca

SUBMITTER: Arjune S 

PROVIDER: S-EPMC10616446 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature