Causal association of circulating cytokines with sepsis: a Mendelian randomization study.

ABSTRACT:

Background

Observational studies have reported an association between circulating cytokines and sepsis. However, the precise causal relationship between these factors remains unclear. The objective of this study was to explore the causal link between circulating cytokines and sepsis using genetic data within the framework of Mendelian Randomization (MR).

Methods

We performed a two-sample MR analysis to investigate this causality relationship in individuals of European ancestry. The publicly available genome-wide association studies (GWAS) statistics were used. We selected eligible instrumental single nucleotide polymorphisms (SNPs) that were significantly related to the circulating cytokines. Multiple MR analysis approaches were carried out, which included inverse variance w

SUBMITTER: Lin S 

PROVIDER: S-EPMC10616607 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature