Lewis acid-promoted direct synthesis of isoxazole derivatives.

ABSTRACT: Isoxazole derivatives were synthesized via a one-pot method utilizing 2-methylquinoline derivatives as template substrates, sodium nitrite as a nitrogen-oxygen source, and solely using aluminum trichloride as the additive. This approach circumvents the need for costly or highly toxic transition metals and presents a novel pathway for the synthesis of isoxazole derivatives.

SUBMITTER: Qiu D 

PROVIDER: S-EPMC10616705 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature