Year-by-Year Blood Pressure Variability From Midlife to Death and Lifetime Dementia Risk.

ABSTRACT:

Importance

High visit-to-visit blood pressure variability (BPV) in late life may reflect increased dementia risk better than mean systolic blood pressure (SBP). Evidence from midlife to late life could be crucial to understanding this association.

Objective

To determine whether visit-to-visit BPV at different ages was differentially associated with lifetime incident dementia risk in community-dwelling individuals.

Design, setting, and participants

This cohort study analyzed data from the Adult Changes in Thought (ACT) study, an ongoing population-based prospective cohort study in the US. Participants were 65 years or older at enrollment, community-dwelling, and without dementia. The study focused on a subset of deceased participants with brain autopsy data and whose m

SUBMITTER: den Brok MGHE 

PROVIDER: S-EPMC10616718 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature