Use of Urea for the Syndrome of Inappropriate Secretion of Antidiuretic Hormone: A Systematic Review.

ABSTRACT:

Importance

Hyponatremia and the syndrome of inappropriate secretion of antidiuretic hormone (SIADH) are associated with significant mortality and morbidity. The effectiveness and safety of oral urea for SIADH are still debated.

Objective

To evaluate the efficacy and safety of urea for the treatment of SIADH.

Evidence review

A systematic search of Medline and Embase was conducted for controlled and uncontrolled studies of urea for SIADH in adult patients. The primary outcome was serum sodium concentration after treatment. Secondary outcomes included the proportion of patients with osmotic demyelination syndrome (ODS), intracranial pressure, and resource use such as length of stay.

Findings

Twenty-three studies involving 537 patients with SIADH were included, of

SUBMITTER: Wendt R 

PROVIDER: S-EPMC10616719 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature