Overall Survival After Treatment Failure Among Patients With Rectal Cancer.

ABSTRACT:

Importance

Oncologic outcomes among patients with rectal cancer after developing local recurrence and/or distant metastases remain poorly studied.

Objective

To analyze the trend of overall survival after treatment failure for patients with rectal cancer within three consecutive phase 2 or 3 trials of the German Rectal Cancer Study Group.

Design, setting, and participants

This cohort study is a post hoc analysis of 3 randomized phase 2 or 3 trials (CAO/ARO/AIO-94, -04, and -12 trials, conducted in Germany) that included 1948 patients with locally advanced rectal adenocarcinoma. The CAO/ARO/AIO-94 trial recruited patients between February 1995 and September 2002, the CAO/ARO/AIO-04 trial recruited patients between July 2006 and February 2010, and the CAO/ARO/AIO-12 tria

SUBMITTER: Diefenhardt M 

PROVIDER: S-EPMC10616722 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature