Evaluation of contributors to amide proton transfer-weighted imaging and nuclear Overhauser enhancement-weighted imaging contrast in tumors at a high magnetic field.

ABSTRACT:

Purpose

The purpose is to evaluate the relative contribution from confounding factors (T₁ weighting and magnetization transfer) to the CEST ratio (CESTR)-quantified amide proton transfer (APT) and nuclear Overhauser enhancement (NOE) (-3.5) in tumors as well as whether the CESTR can reflect the distribution of the solute concentration (f_s ).

Methods

We first provided a signal model that shows the separate dependence of CESTR on these confounding factors and the clean CEST/NOE effects quantified by an apparent exchange-dependent relaxation (AREX) method. We then measured the change in these effects in the 9-L tumor model in rats, through which we calculated the relative contribution of each confounding factor. f_s was also fitted, and its corre

SUBMITTER: Cui J 

PROVIDER: S-EPMC10616782 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature