Landscape of tumor and immune system cells-derived exosomes in lung cancer: mediators of antitumor immunity regulation.

ABSTRACT: The immune system plays a critical role in cancer, including lung cancer, which is the leading cause of cancer-related deaths worldwide. Immunotherapy, particularly immune checkpoint blockade, has revolutionized the treatment of lung cancer, but a large subset of patients either do not respond or develop resistance. Exosomes, essential mediators of cell-to-cell communication, exert a profound influence on the tumor microenvironment and the interplay between cancer and the immune system. This review focuses on the role of tumor-derived exosomes and immune cells-derived exosomes in the crosstalk between these cell types, influencing the initiation and progression of lung cancer. Depending on their cell of origin and microenvironment, exosomes can contain immunosuppressive or immunostimulator

SUBMITTER: Castillo-Pena A 

PROVIDER: S-EPMC10616833 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature