Midgut microbiota affects the intestinal barrier by producing short-chain fatty acids in Apostichopus japonicus.

ABSTRACT:

Introduction

The intestinal microbiota participates in host physiology and pathology through metabolites, in which short-chain fatty acids (SCFAs) are considered principal products and have extensive influence on intestine homeostasis. It has been reported that skin ulceration syndrome (SUS), the disease of Apostichopus japonicus caused by Vibrio splendidus, is associated with the alteration of the intestinal microbiota composition.

Method

To investigate whether the intestinal microbiota affects A. japonicus health via SCFAs, in this study, we focus on the SCFA profiling and intestinal barrier function in A. japonicus treated with V. splendidus.

Results and discussion

We found that V. splendidus could destroy the mid-intestine

SUBMITTER: Song M 

PROVIDER: S-EPMC10616862 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature