A longitudinal rat model for assessing postoperative recovery and bone healing following tibial osteotomy and plate fixation.

ABSTRACT:

Background

Rodent models are commonly employed to validate preclinical disease models through the evaluation of postoperative behavior and allodynia. Our study investigates the dynamic interplay between pain and functional recovery in the context of traumatic osteotomy and surgical repair. Specifically, we established a rat model of tibial osteotomy, followed by internal fixation using a 5-hole Y-plate with 4 screws, to explore the hypothesis that histological bone healing is closely associated with functional recovery.

Objective

Our primary objective was to assess the correlation between bone healing and functional outcomes in a rat model of tibial osteotomy and plate fixation.

Methods

Seventeen male Sprague-Dawley rats underwent a metaphyseal transverse osteotomy of

SUBMITTER: Fan Y 

PROVIDER: S-EPMC10617055 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature