Galantamine ameliorates experimental pancreatitis.

ABSTRACT:

Background

Acute pancreatitis is a common and serious inflammatory condition currently lacking disease modifying therapy. The cholinergic anti-inflammatory pathway (CAP) is a potent protective anti-inflammatory response activated by vagus nerve-dependent α7 nicotinic acetylcholine receptor (α7nAChR) signaling using splenic CD4⁺ T cells as an intermediate. Activating the CAP ameliorates experimental acute pancreatitis. Galantamine is an acetylcholinesterase inhibitor (AChEI) which amplifies the CAP via modulation of central muscarinic ACh receptors (mAChRs). However, as mAChRs also activate pancreatitis, it is currently unknown whether galantamine would be beneficial in acute pancreatitis.

Methods

The effect of galantamine (1-6 mg/kg-body weight) on caerulein-induc

SUBMITTER: Thompson DA 

PROVIDER: S-EPMC10617083 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature