Roastgsa: a comparison of rotation-based scores for gene set enrichment analysis.

ABSTRACT:

Background

Gene-wise differential expression is usually the first major step in the statistical analysis of high-throughput data obtained from techniques such as microarrays or RNA-sequencing. The analysis at gene level is often complemented by interrogating the data in a broader biological context that considers as unit of measure groups of genes that may have a common function or biological trait. Among the vast number of publications about gene set analysis (GSA), the rotation test for gene set analysis, also referred to as roast, is a general sample randomization approach that maintains the integrity of the intra-gene set correlation structure in defining the null distribution of the test.

Results

We present roastgsa, an R package that contains several enrichment score f

SUBMITTER: Caballe-Mestres A 

PROVIDER: S-EPMC10617084 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature