GAD1 contributes to the progression and drug resistance in castration resistant prostate cancer.

ABSTRACT:

Background

Prostate cancer is currently the second most lethal malignancy in men worldwide due to metastasis and invasion in advanced stages. Studies have revealed that androgen deprivation therapy can induce stable remission in patients with advanced prostate cancer, although most patients will develop castration-resistant prostate cancer (CRPC) in 1-2 years. Docetaxel and enzalutamide improve survival in patients with CRPC, although only for a short time, eventually patients develop primary or secondary resistance, causing disease progression or biochemical relapse.

Methods

The gene expression profiles of docetaxel-sensitive or -resistant prostate cancer cell lines, namely GSE33455, GSE36135, GSE78201, GSE104935, and GSE143408, were sequentially analyzed for differentially

SUBMITTER: Wan L 

PROVIDER: S-EPMC10617133 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature