Assessing the safety of lipid-modifying medications among Chinese adolescents: a drug-target Mendelian randomization study.

ABSTRACT:

Background

With increasing hypercholesterolemia prevalence in East Asian adolescents, pharmacologic interventions (e.g., HMGCR inhibitors (statins) and PCSK9 inhibitors) may have to be considered although their longer-term safety in the general adolescent population is unclear. This study aims to investigate the longer-term safety of HMGCR inhibitors and PCSK9 inhibitors among East Asian adolescents using genetics.

Methods

A drug-target Mendelian randomization study leveraging the Global Lipid Genetics Consortium (East Asian, n = 146,492) and individual-level data from Chinese participants in the Biobank clinical follow-up of Hong Kong's "Children of 1997" birth cohort (n = 3443, aged ~ 17.6 years). Safety outcomes (n = 100) included anthropometric and hematological traits,

SUBMITTER: Luo S 

PROVIDER: S-EPMC10617134 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature