Engineered extracellular vesicles for ischemic stroke: a systematic review and meta-analysis of preclinical studies.

ABSTRACT:

Background

This systematic review and meta-analysis aimed to evaluate the efficacy of engineered extracellular vesicles (EEVs) in the treatment of ischemic stroke (IS) in preclinical studies and to compare them with natural extracellular vesicles (EVs). The systematic review provides an up-to-date overview of the current state of the literature on the use of EEVs for IS and informs future research in this area.

Methods

We searched PubMed, EMBASE, Web of Science, Cochrane Library, and Scopus databases for peer-reviewed preclinical studies on the therapeutic effect of EEVs on IS.Databases ranged from the inception to August 1, 2023. The outcome measures included infarct volumes, neurological scores, behavioral scores, apoptosis rates, numbers of neurons, and levels of IL-1β, I

SUBMITTER: Li P 

PROVIDER: S-EPMC10617166 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature