NFAT1 and NFκB regulates expression of the common γ-chain cytokine receptor in activated T cells.

ABSTRACT:

Introduction

Cytokines of the common γ chain (γc) family are critical for the development, differentiation, and survival of T lineage cells. Cytokines play key roles in immunodeficiencies, autoimmune diseases, allergies, and cancer. Although γc is considered an assistant receptor to transmit cytokine signals and is an indispensable receptor in the immune system, its regulatory mechanism is not yet well understood.

Objective

This study focused on the molecular mechanisms that γc expression in T cells is regulated under T cell receptor (TCR) stimulation.

Methods

The γc expression in TCR-stimulated T cells was determined by flow cytometry, western blot and quantitative RT-PCR. The regulatory mechanism of γc expression in activated T cells was examined by promoter-lucifer

SUBMITTER: Shim JA 

PROVIDER: S-EPMC10617197 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature