Hoffmann's syndrome in the differential work-up of myopathic complaints: a case report.

ABSTRACT:

Background

Hoffmann's syndrome is a rare form of hypothyroid myopathy in adults, which is mainly characterized by muscular weakness and muscular pseudohypertrophy.

Case presentation

We report about a 61-year-old Western European man with myalgia, myxedema and pseudohypertrophy of the calf muscles. Laboratory tests revealed significantly elevated thyroid stimulating hormone (TSH) and creatine kinase (CK). Muscle MRI showed muscular hypertrophy of the lower limbs, but no signs of myositis or myopathy (no gadolinium enhancement, no edema, no fatty degeneration). In addition, electromyography (EMG) detected spontaneous activity. After the beginning of thyroxin-therapy it took six months until the muscle weakness improved and the myalgia regressed.

Conclusions

Here, we foc

SUBMITTER: Winter S 

PROVIDER: S-EPMC10617199 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature