Metabolic disorders and risk of cardiovascular diseases: a two-sample mendelian randomization study.

ABSTRACT:

Background

Metabolic disorders are increasing worldwide and are characterized by various risk factors such as abdominal obesity, insulin resistance, impaired glucose metabolism, and dyslipidemia. Observational studies suggested a bidirectional association between cardiovascular diseases and metabolic disorders and its components. However, the causal associations between them remained unclear. This study aims to investigate the causal relationship between metabolic disorders and cardiovascular disease through Mendelian randomization (MR) analysis.

Methods

A two-sample MR analysis based on publicly available genome-wide association studies were used to infer the causality. The single-nucleotide polymorphisms with potential pleiotropy were excluded by MR-PRESSO. The effect esti

SUBMITTER: Wang Z 

PROVIDER: S-EPMC10617200 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature